Punicalagin Prevents Inflammation in LPS- Induced RAW264.7 Macrophages by Inhibiting FoxO3a/Autophagy Signaling Pathway
Identifieur interne : 000500 ( Main/Exploration ); précédent : 000499; suivant : 000501Punicalagin Prevents Inflammation in LPS- Induced RAW264.7 Macrophages by Inhibiting FoxO3a/Autophagy Signaling Pathway
Auteurs : Yuan Cao ; Jihua Chen ; Guofeng Ren ; Yahui Zhang ; Xiuying Tan ; Lina YangSource :
- Nutrients [ 2072-6643 ] ; 2019.
Abstract
Punicalagin, a hydrolysable tannin of pomegranate juice, exhibits multiple biological effects, including inhibiting production of pro-inflammatory cytokines in macrophages. Autophagy, an intracellular self-digestion process, has been recently shown to regulate inflammatory responses. In this study, we investigated the anti-inflammatory potential of punicalagin in lipopolysaccharide (LPS) induced RAW264.7 macrophages and uncovered the underlying mechanisms. Punicalagin significantly attenuated, in a concentration-dependent manner, LPS-induced release of NO and decreased pro-inflammatory cytokines TNF-α and IL-6 release at the highest concentration. We found that punicalagin inhibited NF-κB and MAPK activation in LPS-induced RAW264.7 macrophages. Western blot analysis revealed that punicalagin pre-treatment enhanced LC3II, p62 expression, and decreased Beclin1 expression in LPS-induced macrophages. MDC assays were used to determine the autophagic process and the results worked in concert with Western blot analysis. In addition, our observations indicated that LPS-induced releases of NO, TNF-α, and IL-6 were attenuated by treatment with autophagy inhibitor chloroquine, suggesting that autophagy inhibition participated in anti-inflammatory effect. We also found that punicalagin downregulated FoxO3a expression, resulting in autophagy inhibition. Overall these results suggested that punicalagin played an important role in the attenuation of LPS-induced inflammatory responses in RAW264.7 macrophages and that the mechanisms involved downregulation of the FoxO3a/autophagy signaling pathway.
Url:
DOI: 10.3390/nu11112794
PubMed: 31731808
PubMed Central: 6893462
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Punicalagin Prevents Inflammation in LPS- Induced RAW264.7 Macrophages by Inhibiting FoxO3a/Autophagy Signaling Pathway</title><author><name sortKey="Cao, Yuan" sort="Cao, Yuan" uniqKey="Cao Y" first="Yuan" last="Cao">Yuan Cao</name></author><author><name sortKey="Chen, Jihua" sort="Chen, Jihua" uniqKey="Chen J" first="Jihua" last="Chen">Jihua Chen</name></author><author><name sortKey="Ren, Guofeng" sort="Ren, Guofeng" uniqKey="Ren G" first="Guofeng" last="Ren">Guofeng Ren</name></author><author><name sortKey="Zhang, Yahui" sort="Zhang, Yahui" uniqKey="Zhang Y" first="Yahui" last="Zhang">Yahui Zhang</name></author><author><name sortKey="Tan, Xiuying" sort="Tan, Xiuying" uniqKey="Tan X" first="Xiuying" last="Tan">Xiuying Tan</name></author><author><name sortKey="Yang, Lina" sort="Yang, Lina" uniqKey="Yang L" first="Lina" last="Yang">Lina Yang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31731808</idno><idno type="pmc">6893462</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893462</idno><idno type="RBID">PMC:6893462</idno><idno type="doi">10.3390/nu11112794</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000734</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000734</idno><idno type="wicri:Area/Pmc/Curation">000734</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000734</idno><idno type="wicri:Area/Pmc/Checkpoint">000456</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000456</idno><idno type="wicri:Area/Ncbi/Merge">000C12</idno><idno type="wicri:Area/Ncbi/Curation">000C12</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C12</idno><idno type="wicri:Area/Main/Merge">000500</idno><idno type="wicri:Area/Main/Curation">000500</idno><idno type="wicri:Area/Main/Exploration">000500</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Punicalagin Prevents Inflammation in LPS- Induced RAW264.7 Macrophages by Inhibiting FoxO3a/Autophagy Signaling Pathway</title><author><name sortKey="Cao, Yuan" sort="Cao, Yuan" uniqKey="Cao Y" first="Yuan" last="Cao">Yuan Cao</name></author><author><name sortKey="Chen, Jihua" sort="Chen, Jihua" uniqKey="Chen J" first="Jihua" last="Chen">Jihua Chen</name></author><author><name sortKey="Ren, Guofeng" sort="Ren, Guofeng" uniqKey="Ren G" first="Guofeng" last="Ren">Guofeng Ren</name></author><author><name sortKey="Zhang, Yahui" sort="Zhang, Yahui" uniqKey="Zhang Y" first="Yahui" last="Zhang">Yahui Zhang</name></author><author><name sortKey="Tan, Xiuying" sort="Tan, Xiuying" uniqKey="Tan X" first="Xiuying" last="Tan">Xiuying Tan</name></author><author><name sortKey="Yang, Lina" sort="Yang, Lina" uniqKey="Yang L" first="Lina" last="Yang">Lina Yang</name></author></analytic><series><title level="j">Nutrients</title><idno type="eISSN">2072-6643</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Punicalagin, a hydrolysable tannin of pomegranate juice, exhibits multiple biological effects, including inhibiting production of pro-inflammatory cytokines in macrophages. Autophagy, an intracellular self-digestion process, has been recently shown to regulate inflammatory responses. In this study, we investigated the anti-inflammatory potential of punicalagin in lipopolysaccharide (LPS) induced RAW264.7 macrophages and uncovered the underlying mechanisms. Punicalagin significantly attenuated, in a concentration-dependent manner, LPS-induced release of NO and decreased pro-inflammatory cytokines TNF-α and IL-6 release at the highest concentration. We found that punicalagin inhibited NF-κB and MAPK activation in LPS-induced RAW264.7 macrophages. Western blot analysis revealed that punicalagin pre-treatment enhanced LC3II, p62 expression, and decreased Beclin1 expression in LPS-induced macrophages. MDC assays were used to determine the autophagic process and the results worked in concert with Western blot analysis. In addition, our observations indicated that LPS-induced releases of NO, TNF-α, and IL-6 were attenuated by treatment with autophagy inhibitor chloroquine, suggesting that autophagy inhibition participated in anti-inflammatory effect. We also found that punicalagin downregulated FoxO3a expression, resulting in autophagy inhibition. Overall these results suggested that punicalagin played an important role in the attenuation of LPS-induced inflammatory responses in RAW264.7 macrophages and that the mechanisms involved downregulation of the FoxO3a/autophagy signaling pathway.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gu, L" uniqKey="Gu L">L. Gu</name></author><author><name sortKey="Kelm, M A" uniqKey="Kelm M">M.A. Kelm</name></author><author><name sortKey="Hammerstone, J F" uniqKey="Hammerstone J">J.F. Hammerstone</name></author><author><name sortKey="Beecher, G" uniqKey="Beecher G">G. 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Kroemer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cao, Yuan" sort="Cao, Yuan" uniqKey="Cao Y" first="Yuan" last="Cao">Yuan Cao</name><name sortKey="Chen, Jihua" sort="Chen, Jihua" uniqKey="Chen J" first="Jihua" last="Chen">Jihua Chen</name><name sortKey="Ren, Guofeng" sort="Ren, Guofeng" uniqKey="Ren G" first="Guofeng" last="Ren">Guofeng Ren</name><name sortKey="Tan, Xiuying" sort="Tan, Xiuying" uniqKey="Tan X" first="Xiuying" last="Tan">Xiuying Tan</name><name sortKey="Yang, Lina" sort="Yang, Lina" uniqKey="Yang L" first="Lina" last="Yang">Lina Yang</name><name sortKey="Zhang, Yahui" sort="Zhang, Yahui" uniqKey="Zhang Y" first="Yahui" last="Zhang">Yahui Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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